14-3-3 theta anticorps (pSer58)

N° du produit ABIN5688906

Cet anticorps Lapin Polyclonal détecte spécifiquement 14-3-3 theta dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien, Xenopus laevis, Poisson zèbre (Danio rerio) et Mouton.

Aperçu rapide pour 14-3-3 theta anticorps (pSer58) (ABIN5688906)

Antigène: 14-3-3 theta (YWHAQ)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien, Xenopus laevis, Poisson zèbre (Danio rerio), Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 14-3-3 theta est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-14-3-3 theta anticorps

Épitope: pSer58

Purification: Affinity Purified

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser58 of rat 14-3-3 protein.

Information d'application

Indications d'application: The antibody has been directly tested for reactivity in Western blots with human and rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, mouse, non-human primates, sheep, Xenopus and zebra fish based on the fact that these species have 100 % homology with the amino acid sequence used as antigen for this antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: 14-3-3 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Détails sur 14-3-3 theta

Antigène: 14-3-3 theta (YWHAQ)

Autre désignation: 14-3-3

Sujet: 14-3-3 proteins are a family of highly conserved proteins that appear to have multiple roles in cell signaling (Bridges and Moorhead, 2005). The proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders (Berg et al., 2003). 14-3-3 proteins bind protein ligands that are typically phosphorylated on serine or threonine residues and regulate the functions of these binding partners by a number of different mechanisms (Silhan et al., 2004, Dougherty and Morrison, 2004). The14-3-3 proteins affect a diverse array of cellular processes including the cell cycle and transcription, signal transduction and intracellular trafficking. These functions of 14-3-3 proteins are facilitated by, if not dependent on, its dimeric structure. Recent work has demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation (Woodcock et al., 2003).

Poids moléculaire: 29 kDa

ID gène: 56011

UniProt: P35213

Pathways: Apoptose, Myometrial Relaxation and Contraction